Easier-to-use diabetes drug passes test
Lilly, Amylin says studies reveal experimental, but longer-lasting version of Byetta is effective.
By Aaron Smith, CNNMoney.com staff writer

WASHINGTON (CNNMoney.com) - Eli Lilly & Co. and Amylin, makers of the diabetes treatment Byetta, reported Saturday that a more convenient-to-use but experimental version of the drug successfully reduces blood-sugar levels.

Byetta, a potential blockbuster, has been on the market since June 1, 2005 to help diabetics with type 2, or the most common type of diabetes, control blood-sugar levels. The drug is injected twice a day, but a study released at the annual conference of the American Diabetes Association showed that an experimental once-a-week version is also effective.

The study showed that the long-acting release, or LAR, version of Byetta successfully controlled blood-sugar levels in 86 percent of patients taking high doses, compared to 33 percent with lower doses and 2 percent with placebo. This study was conducted on 45 patients over 15 weeks by Lilly (Research), an Indianapolis drugmaker, Amylin (Research), a San Diego biotech, and Cambridge, Mass.-based partner Alkermes (Research).

Continuing the original study that led to FDA approval, Lilly and Amylin also announced that 50 percent of Byetta patients successfully reduced blood-sugar levels over two years to a medically acceptable target and lost an average of 10 pounds.

In an additional study released Saturday, Lilly and Amylin said that Byetta, when used with TZDs, or pills that help the body use insulin, alone or in combination with metformin, a generic blood-sugar drug, successfully reduced blood sugar to a medically acceptable target 62 percent of the time.

Sales from Byetta, which is derived from the saliva of the Gila monster, totaled $68 million in the first quarter, which was split between Lilly and Amylin. Philip Nadeau, analyst for Cowen & Co., projects that annual sales will total $400 million in 2006 and $1.5 billion by 2010, to be divided among the two companies.

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Also at the diabetes conference: Vytorin vs. Lipitor in the cholesterol-fighting war

FDA OK's Lilly and Amylin diabetes drug. Top of page

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Most stock quote data provided by BATS. Market indices are shown in real time, except for the DJIA, which is delayed by two minutes. All times are ET. Disclaimer.

Morningstar: © 2014 Morningstar, Inc. All Rights Reserved.

Factset: FactSet Research Systems Inc. 2014. All rights reserved.

Chicago Mercantile Association: Certain market data is the property of Chicago Mercantile Exchange Inc. and its licensors. All rights reserved.

Dow Jones: The Dow Jones branded indices are proprietary to and are calculated, distributed and marketed by DJI Opco, a subsidiary of S&P Dow Jones Indices LLC and have been licensed for use to S&P Opco, LLC and CNN. Standard & Poor's and S&P are registered trademarks of Standard & Poor’s Financial Services LLC and Dow Jones is a registered trademark of Dow Jones Trademark Holdings LLC. All content of the Dow Jones branded indices © S&P Dow Jones Indices LLC 2014 and/or its affiliates.