Obama beat out Sen. John McCain in mask sales in 2008 with the same split as this year. The retailer also predicted a President George W. Bush win over Sen. John Kerry in 2004, a 2000 Bush victory over former Vice President Al Gore, and a Sen. Bob Dole defeat by President Bill Clinton in 1996.
"A lot of people are going out and supporting their candidate by wearing their masks," said Lisa Barr, senior director of marketing for Spirit Halloween.
The face-off between Obama and Romney masks, which retail at Spirit for between $19.99 and $21.99, aren't the only election-related costumes sparking sales for Oct. 31.
Big Bird costumes have been flying off the shelves since the first presidential debate, when Romney said he would cut funding for PBS, the TV home of Sesame Street. Google searches for Big Bird costumes on the Internet also rose 600% after that debate.
Yon Zweibon, owner of Beyond Costumes in Yonkers, N.Y., said she got a flood of calls coming in to rent the store's big yellow bird costume this year.
At Ricky's, another Halloween and beauty store chain, Big Bird is the fifth most popular costume for adults, behind Pirates of the Caribbean's Jack Sparrow and Catwoman.
A record number of 170 million people plan to celebrate Halloween this year, according to the National Retail Federation's 2012 consumer spending survey conducted by BIGinsight. The average person will spend nearly $80 on costumes, candy and decoration, $8 more than last year.