President Obama said in a statement that he was "pleased that the Senate took bipartisan action today to confirm Jack Lew as our nation's next Treasury secretary."
"His reputation as a master of fiscal issues who can work with leaders on both sides of the aisle has already helped him succeed in some of the toughest jobs in Washington," Obama said.
Republicans who voted against Lew said they were concerned about his experience at Citigroup(C) during the financial crisis. Lew had served as the chief operating officer at Citi Alternative Investments in 2008, which made bets against the housing market.
Lawmakers questioned an offshore investment in the Cayman Islands and a $900,000 bonus Lew received even as the bank was being bailed out by taxpayers.
"In the past, the president has railed again the 'fat cats' on Wall Street," Sen. Charles Grassley of Iowa, who opposed the confirmation, said Wednesday. "Today, the president nominates a man who took a bonus from a bailed-out financially insolvent bank.
Lew has said he did not make investment decisions at Citigroup and that he has paid taxes on all his investments, many of which he sold for a loss.
Other Republicans and some on Wall Street have said they're concerned about Lew's lack of business and financial markets experience.
Still, Lew garnered a stronger confirmation vote than his predecessor, Tim Geithner, who took office in 2009, after a 60-34 Senate vote.
Lew is expected to jump right in to the debate over how to address some $85 billion in forced budget cuts that are scheduled to hit Friday. He was part of the team that came up with the original idea of the cuts, as a key player in the 2011 debt ceiling talks. At the time, nobody thought the cuts would ever come to pass, as they were intended to be so horrible that they'd force a budget deal.