Global 500 rank: 115 (Previous rank: 101)
Profits (millions): $19,337
Change from 2005: 139.2%
Get quote: PFE
Pfizer badly needs a new blockbuster drug to buoy its performance -- earnings in 2005 fell 28.8%. In 2006 the pharmaceutical giant managed to post a 139% earnings gain thanks to layoffs and the sale of its consumer-products division to Johnson & Johnson.
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