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13. Express Scripts
Express Scripts
Fortune 500 rank: 135
2007 revenue: $18.38 billion
2007 total shareholder return: 103.9%

The pharmacy-benefits manager tried to buy rival Caremark but was outbid by CVS. However, it had the last laugh: Its stock performed considerably better than the drugstore chain's, as profits rose 19.7%, to $568 million.

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Last updated April 24 2008: 10:54 AM ET
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