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15. Medco Health Solutions

• See more Fortune 500 data for Medco

Fortune 500 rank: 51

2007 revenue: $44.51 billion

2007 total shareholder return: 89.7%

The second pharmacy-benefits manager on our list, Medco is the biggest in the field. The company, based in Franklin Lakes, N.J., notched profits of $912 million -- up 44.7% from 2006 -- thanks in part to robust growth in its lucrative mail-order business.

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Last updated April 24 2008: 10:54 AM ET

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