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12. Cisco Systems
Fortune rank: 12
2008 profit: $8.05 Billion
Cisco, the tech giant known for Internet routers and networking equipment, continued growing in new areas like data storage and video conferencing.

Profits grew 10% to $8.1 billion in 2008. Led by CEO John Chambers, the company increased cash reserves to $26 billion as other Silicon Valley firms struggled to survive the downturn.

NEXT: Merck
Last updated April 20 2009: 11:09 AM ET
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