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12. United Parcel Service
United Parcel Service
Jobs lost: 18,000
% drop (1 year): 4%
Remaining employees*: 408,000
Fortune 500 rank: 43

Lower shipping volume and declining sales forced the package deliverer to cut back on its workforce. Earlier this year, the company announced restructuring plans to eliminate 1,800 administrative and management positions and 300 pilots over the next three years.

NEXT: Hewlett-Packard

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Last updated May 13 2010: 9:10 AM ET
* Full-time equivalent employees as of the end of 2009
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