3. First Trust Amex Biotech Index ETF
Ticker: FBT
YTD Return: 36%
Market cap: $251 million
Expense ratio: 0.60%

Despite the ups and downs in the broader stock market, the biotechnology sector has remained resilient this year, largely thanks to robust merger activity.

"A lot of big pharmaceuticals are running out of drug patents and are replenishing their pipeline by buying up smaller biotech companies," said John Spence, web editor of ETFtrends.com.

For example, shares of Human Genome Sciences (HGSI), which is a major holding in the ETF, have shot up more than 80% this year as pharmaceutical giant GlaxoSmithKline (GSK) pursued the company. After rejecting a bid back in April, Human Genome accepted GSK's offer of $3.6 billion earlier this week.

The deals and speculation over takeover targets have pushed the biotech ETF near all-time highs.



All data from global ETF research firm XTF as of market's close on July 6, 2012.
By Hibah Yousuf @CNNMoneyInvest - Last updated July 17 2012: 9:17 PM ET
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