As of 4:00pm ET
| -0.036 / -5.75%|
Trovagene, Inc. is a clinical-stage, precision medicine oncology therapeutics company. Trovagene's lead drug candidate, PCM-075, is a Polo-like Kinase 1 (PLK1) selective adenosine triphosphate (ATP) competitive inhibitor. PCM-075 has shown preclinical antitumor activity as a single agent and in synergy combinations with more than ten different chemotherapeutics and targeted therapies, such as Zytiga (abiraterone acetate), Beleodaq (belinostat), Quizartinib (AC220), a development stage FLT3 inhibitor, and Velcade (bortezomib) in Acute Myeloid Leukemia (AML), metastatic Castration-Resistant Prostate Cancer (mCRPC) and other liquid and solid tumor cancers. PCM-075 was developed to have high selectivity to PLK1, to be administered orally, and to have a relatively short drug half-life of approximately 24 hours compared to other PLK inhibitors. PCM-075 has completed a safety study in patients with advanced metastatic solid tumors with a phase 1b/2 clinical trial in patients with AML underway. The company was founded by Gabriel M. Cerrone, L. David Tomei, Samuil Umansky and Hovsep Melkonyan on August 4, 1999 and is headquartered in San Diego, CA.
|Bill Welch||President, Chief Executive Officer & Director|
|Mark Erlander||Chief Scientific Officer|
|Karsten Schmidt||Chief Technology Officer|
|Elizabeth Anderson||Vice President-Finance & Administration|
|Nick Nelson||Vice President-Strategy & Corporate Development|