| 0.43 Data as of 11:50am ET |  -0.005 / -1.15%Today’s Change | 0.28 Today|||52-Week Range 0.89 | -21.10% Year-to-Date |
| Other institutional | 61.21% |
| Individual stakeholders | 23.35% |
| Mutual fund holders | 14.75% |
| 3/31/2013 | T. ROWE PRICE ASSOCIATES, INC. Bought 11.9 Million shares of A.P. Pharma Inc |
| 5/01/2013 | TANG CAPITAL MANAGEMENT LLC Bought 5.7 Million shares of A.P. Pharma Inc |
| 3/31/2013 | COUGAR TRADING LLC Bought 200.0 Thousand shares of A.P. Pharma Inc |
| Stockholder | Stake | Shares owned | Total value ($) | Shares bought / sold | Total change |
|---|---|---|---|---|---|
| Tang Capital Management LLC | 23.13% | 70,679,785 | 25,727,442 | +5,746,716 | +8.85% |
| Savitr Capital LLC | 11.84% | 36,190,476 | 13,173,333 | 0 | 0.00% |
| Baker Bros. Advisors LLC | 8.46% | 25,855,851 | 9,411,530 | +8,994,033 | +53.34% |
| Franklin Advisers, Inc. | 6.90% | 21,093,000 | 7,677,852 | -1,193,201 | -5.35% |
| Perceptive Advisors LLC | 6.01% | 18,352,404 | 6,680,275 | -8,314,263 | -31.18% |
| Tekla Capital Management LLC | 5.34% | 16,306,333 | 5,935,505 | -3,693,668 | -18.47% |
| Broadfin Capital LLC | 5.08% | 15,523,810 | 5,650,667 | +15,523,810 | -- |
| T. Rowe Price Associates, Inc. | 4.80% | 14,666,300 | 5,338,533 | +11,928,200 | +435.64% |
| BVF, Inc. | 4.35% | 13,283,334 | 4,835,134 | -50,000 | -0.37% |
| Cougar Trading LLC | 0.07% | 200,000 | 72,800 | +200,000 | -- |
| Mutual fund | Stake | Shares owned | Total value ($) | Shares bought / sold | Total change |
|---|---|---|---|---|---|
| T Rowe Price Health Sciences Fund | 3.74% | 11,430,000 | 4,160,520 | +11,430,000 | -- |
| Franklin Biotechnology Discovery ... | 3.57% | 10,900,000 | 3,967,600 | +6,797 | +0.06% |
| FTIF SICAV - Franklin Biotechnolo... | 3.23% | 9,869,400 | 3,592,462 | -323,600 | -3.17% |
| H&Q Healthcare Investors Fund | 2.18% | 6,651,340 | 2,421,088 | -2,167,829 | -24.58% |
| H&Q Life Sciences Investors Fund | 0.98% | 2,988,326 | 1,087,751 | -973,953 | -24.58% |
| John Hancock Funds II Health Scie... | 0.38% | 1,163,100 | 423,368 | 0 | 0.00% |
| VALIC Company I-Health Sciences F... | 0.24% | 727,500 | 264,810 | 0 | 0.00% |
| TD Health Sciences Fund | 0.16% | 486,200 | 176,977 | +486,200 | -- |
| John Hancock VIT-Health Sciences ... | 0.15% | 466,500 | 169,806 | 0 | 0.00% |
| T Rowe Price Health Sciences Port... | 0.13% | 393,000 | 143,052 | +12,000 | +3.15% |
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