Weight Watchers began 50 years ago as a regular meeting in founder Jean Nidetch's apartment.
Take a look inside Wilson Football factory in Ada, Ohio where the official Super Bowl game balls are made.
Take a look inside a small business that harvests and ships about 1 million pounds of eels a year.
About 30% of the components of a Marshall amplifier are still installed by hand at the historic company's factory.
Jelly Belly saw a jump in sales after the former President became a huge fan and passed out jars of the flavored jelly beans to world leaders.
Originally invented to utilize pans during strawberry shortcake off-season, the Twinkie became an emblematic American snack.
The family-owned business introduced flavored tea to the U.S. more than 60 years ago and has become the number one specialty tea company in the country.
Margins on tobacco farming have slimmed with lower demand, so Richard Renegar started a hunting business on his land.
Welch's concord grape juice was invented over 140 years ago as non-alcoholic wine for the church services.
Raul Ojeda started shining shoes at the age of 18. A decade later, with the help of his mentor, Willie, he owns his own small business.
Goya says it became the U.S.'s biggest Hispanic-owned food company by catering to the tastes of varied Latin-American groups.
The manufacturer of pianos has passed the skills of making the musical instrument generation after generation for over 150 years.
Brad Barrett turned a grilling system patent into his own business after years working in chemical industry product development.
For over 100 years, Crayola has mixed and molded crayons in the hopes of encouraging creativity in children.
After raising chickens on a farm became a lonely task, Jim Herr purchased a small potato chip company and built it into a snack-making empire.
Pink's Hot Dogs, the iconic Los Angeles eatery, opened in 1939 as a pushcart selling hot dogs for just ten cents.
The customer review site started as a magazine and call-in service with Angie Hicks going door-to-door to get people to sign up for a subscription.
The Western Costume Co. has been dressing Hollywood since the days of silent film. Here's how they got started 100 years ago.
Don't call it a pigskin. Horween Leather Co. starts with a raw cowhide and produces top grade leather for NFL footballs.
Despite its foreign-looking name, Haagen-Dazs was the brainchild of a young entrepreneur who grew up selling ice cream in New York.
Yuengling brewery started nearly 200 years ago in Pottsville, Penn. It turns out more than 2 million barrels of beer a year and is still family-owned.
Other manufacturers have tried and failed to duplicate the classic toy, which is why every slinky sold in the world is still made in the U.S.A.
Chick-fil-A founder Truett Cathy started his first business at 8 years old, and is credited with creating the fast food chicken sandwich.
Fashion designer Eileen Fisher didn't even know how to sew when she started her clothing company but had the determination to succeed.
The café's founder Ron Shaich turned around a struggling French bakery and a sandwich shop and created a national brand.
The founder of Rue La La discusses his road to success in the online bargain biz.
The 100-year-old family business is ripe for the picking by bigger companies, but its owners won't bite.
Founder and CEO David Overton explains how The Cheesecake Factory all started with a simple recipe cooked up in a Detroit basement.
A look at how Just Born, the family-run business behind the marshmallow treat, got its start in the candy biz.
Tito Beveridge's love of vodka helped him start Tito's Vodka, a highly successful handmade distillery business outside of Austin, Texas.
Louis Black's love of music and movies inspired him and his partners to start SXSW, one of the most successful conferences in the world.
The maker of high-end paper products from stationary to currency, Crane & Co., has survived the switch to paperless transactions.
The founders of Skip Hop share how they became major players in the baby biz.
Jim Henson created a whole new way of puppeteering for children and adults to enjoy and now his kids continue his legacy.
The restaurant famously known for its Hooters Girls started off as a bar and has since grown into an international brand.
The world's largest family-owned winery has evolved to suit Americans' tastes since its founding in 1933.
Laird & Co. has produced its Apple Jack Brandy since the 18th century, but now it's hipper than ever.
For 80 years this luxury tobacco company has sold its goods to Hollywood's big shots and New York's gangsters.
The spicy pepper sauce is still made the same way it was more than 140 years ago.
With a slew of PG hits, this kid-friendly band has legions of little fans.
Alice Waters' Michelin-rated restaurant grew from her love of French cuisine.
The founders of Harmonix talk about the challenges of starting up a company that fuses music and gaming.
Costco CEO Jim Sinegal on how the wholesale retailer went from concept to $1 billion in just three years.
Josie Natori went from designing sleepwear to managing a brand of home, fragrance and ready-to-wear lines.
The late TV pitchman discusses his start in infomercials.
Co-founder Reid Hoffman explains how the networking site was created to build upon existing relationships.
Founder Noel Lee tells how he set out to 'monsterize the world' with his high-performance wire.
The founders of Amy's Kitchen went from testing recipes in their kitchen to running the nation's leading prepared organic food company.
Tom Szaky's company has a business model that profits from recycling by getting cash for trash.
A look at how the celebrated chef, Nobu, went from being a busboy to a household name.