Table of contents: VOL. 7, NO. 1 - January 1, 2006
Our year-in-review salute to the bold moves, big bets, and brilliant innovations that paid off for dozens of America's most clever companies. (more)

Sanaria's vaccine is but one of many efforts to defeat malaria. Here are some of the most promising. (more)
Scientist Stephen Hoffman may be close to neutralizing one of history's most implacable killers--and forging a new entrepreneurial model for attacking global diseases. (more)
Notorious former mental institutions being converted into high-end condos. Candy bars with curious names. And more stupidity. See our list of the year's most boneheaded blunders. (more)
One of the dumbest and most amusing items rounds out our list. (more)
Our picks for the brainiest businesses and businesspeople of the year. (more)
Top experts help us plot four scenarios that show where the company's geniuses may be leading it--and, perhaps, all of us. (more)
Scott McNealy is giving away software to sell hardware. Will his razor-and-blades strategy put Sun Microsystems back at tech's cutting edge? (more)
what's cool
The business tools you can't work without (more)

Eating right can power you through your next business trip and bring you home with energy--and new ideas--to spare. (more)
With its shapely curves and powerful four-wheel drive, the Range Rover Sport quickly adjusts to just about any terrain--with or without input from you. (more)

what's next

Millions from Yahoo transformed the life of founder Joshua Schachter--and set him up to find the next big thing. (more)
Can hip new listening lounges save Sam Goody? (more)
what works
Have an idea for a startup that could challenge an industry leader? There's never been a better time to come late to the race. (more)
Preserving youth without plastic surgery will soon be a $20 billion business. And that's just scratching the surface. (more)
City Telecom became Hong Kong's second-largest residential Internet provider by treating access like water and power. (more)
Using an existing design as a jumping-off point, Metrokane's popular corkscrew continues to hop past the competition. (more)
A partnership between BP and Hollywood is helping low-income families go green. (more)
Distributed management sounds impractical, but it might help your company play a more innovative tune. (more)
Troubled times make gold an even more precious metal. Here's one way it can protect your treasure. (more)
Our annual rankings show another banner year for the businesses leading the tech revival. Here's who is out in front and how they got there. |more|
It's getting crowded on the Web 2.0 frontier, but we highlight the newcomers most likely to strike gold in 2007. |more|
See the video, test your Dumbest knowledge, and let us know what you think was the year's most boneheaded moves. |more|
The real estate slump could get worse before it gets better. Here are smart strategies for today's turbulent market. |more|
It just may be possible to have it all. Business 2.0's guide shows you how to live large now - and bankroll your future. |more|