The Senate voted 56 to 26 to confirm Janet Yellen the next chair of the Federal Reserve.
Senators voted 56 to 26 in her favor, with many missing the vote because of inclement weather. Eleven Republicans broke party ranks, voting to support Yellen.
She will be the first woman to head the Federal Reserve in its 100-year history.
In a statement, President Obama said he is "confident that Janet will stand up for American workers, protect consumers, foster the stability of our financial system, and help keep our economy growing for years to come."
Yellen brings a robust résumé to the job, including more than a decade in various Fed positions. In her recent role as Fed vice chair, she voiced deep concerns about high unemployment and spoke in favor of the Fed's bond-buying program as a way to stimulate the economy.
Those views closely align with current Chairman Bernanke.
In his two terms as chairman, Bernanke led the Fed through a turbulent eight years that included the deepest recession since the Great Depression. Under his leadership, the Fed has taken unprecedented measures to stimulate the economy, cutting its key interest rate to near zero and buying trillions in bonds.
Bernanke also pushed through reforms to make the famously secretive central bank slightly more transparent. While Fed meetings are still closed to the public, he added press conferences and the release of the Fed's economic projections following four meetings each year.
In a speech last week, Bernanke reflected on his two terms, noting his mission is still not accomplished.
"The recovery clearly remains incomplete," he said.
As Bernanke's successor, Yellen will face a major challenge: How to wean the economy off so much stimulus, first by winding down the latest bond-buying program.
Her first meeting as chair is scheduled for March 18 to 19.
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