5 of 6
BACKNEXT
Saving man's best friend

ApopLogic Pharmaceuticals
Aurora, Colo.

Richard Duke is a tenured faculty member in the department of medicine and immunology at the University of Colorado Cancer Center. He is also a serial entrepreneur. His current startup is ApopLogic Pharmaceuticals, which he cofounded with six other scientists at the Cancer Center. Duke is the company's CEO and a two-time recipient of Small Business Innovation Research (SBIR) grants -- the federal grants that help commercialize technology developed by research or academic institutions.

ApopLogic is focused on developing and selling a treatment for cancer using a protein known as Fas ligand, which kills a variety of cancer cells. One big drawback: It's toxic to the liver. Duke and his scientific partners thought that if Fas ligand could be delivered right where it's needed, into a tumor, it might cause those cancer cells to die without harming the liver. Duke and one of his partners -- Jamie Modiano, a veterinarian -- devised a study that used Fas ligand to treat malignant melanomas in dogs' mouths. Five dogs were treated. A week later, the tumors had shrunk significantly and were removed; 80% of the dogs lived another two years.

Duke says he and his partners knew venture capital financing was unlikely. He instead applied for an SBIR grant to do a much larger clinical study on dogs. These grants are peer-reviewed by other experts in the same field -- the better your credentials and experience, the better your chances of getting a grant.

Duke and his partners received a $700,000 SBIR grant in 2006 to start the company, and have just applied for a Phase II SBIR grant. This time, they're asking for close to $2 million, which would pay for conducting detailed toxicology and pharmacology studies and manufacturing the product to meet FDA standards. Duke also got a grant from the American Kennel Club, for $200,000.

"My desire is to get this into humans, but it could also help dogs," he says. "In biotech, you have to be flexible and adaptable."

NEXT: Training staffers to lead

Email | Print | Share  |  RSS
 
google my aol my msn my yahoo! netvibes
Paste this link into your favorite RSS desktop reader
See all CNNMoney.com RSS FEEDS (close)
LAST UPDATE: Oct 28 2009 | 11:29 AM ET
More Galleries
5 startups that are reimagining the world Bricks that grow from microorganisms, household garbage turned into art, three-wheeled bike-cars -- these startups are redefining urban living. More
Blue collar entrepreneurs These five entrepreneurs took their blue collar experience and used it to launch innovative businesses. More
7 lifehacks to eliminate your holiday hassle Whether curating the perfect gift or finding a pet-sitter, these startups offer time-saving services that might just seem like holiday magic. More
Sponsors

Most stock quote data provided by BATS. Market indices are shown in real time, except for the DJIA, which is delayed by two minutes. All times are ET. Disclaimer. Morningstar: © 2018 Morningstar, Inc. All Rights Reserved. Factset: FactSet Research Systems Inc. 2018. All rights reserved. Chicago Mercantile Association: Certain market data is the property of Chicago Mercantile Exchange Inc. and its licensors. All rights reserved. Dow Jones: The Dow Jones branded indices are proprietary to and are calculated, distributed and marketed by DJI Opco, a subsidiary of S&P Dow Jones Indices LLC and have been licensed for use to S&P Opco, LLC and CNN. Standard & Poor's and S&P are registered trademarks of Standard & Poor's Financial Services LLC and Dow Jones is a registered trademark of Dow Jones Trademark Holdings LLC. All content of the Dow Jones branded indices © S&P Dow Jones Indices LLC 2018 and/or its affiliates.