Company: KeyCorp
Fortune 500 rank: 417
First year as CEO: 2011
Most Powerful Women rank: 49
In May, she took over the regional financial institution with almost $90 billion in assets, making her the only woman to run a large U.S. bank. Second-quarter profits jumped to $243 million, up from $56 million in the same period a year ago, in part due to a fall in loan losses and cuts in expenses.
NEXT: Lynn Elsenhans