Tony Hsieh (l) and Charles Best
Hsieh: CEO, Zappos.com
Age: 38
Industry: Apparel
Hsieh still runs Zappos, but he's attained guru status when it comes to building workplaces: His "Delivering happiness" message is now the basis for a bestselling book and a company that exports his philosophy to giants like P&G and Hasbro.
Latest move: Investing in private jet outfit JetSuite.
Best: Founder, DonorsChoose.org
Age: 36
Industry: Nonprofit
Donations for Best's nonprofit, which raises funds for public school classrooms, are on track for $40 million this school year, nearly double from two years ago, and now total $90 million since 2000. Last year his gift card was among Oprah's "ultimate favorite things."
NEXT: John Janick & Mike Caren