Oprah Winfrey
Oprah Winfrey
Harpo Productions

The queen of daytime television left one of the highest-rated programs in history last year to significantly expand her portfolio with the launch of a cable network, OWN. Winfrey, 58, leveraged her celebrity to create a business empire spanning one of the most successful magazines in the world, movies, and television.


This story is from the April 9, 2012 issue of Fortune.
By John A. Byrne, contributor @FortuneMagazine - Last updated March 22 2012: 6:02 AM ET
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