eBay's Meg Whitman

NEW YORK (CNN/Money) - Meg rules again.

eBay chief executive Meg Whitman has been ranked the most powerful woman in business for the second straight year, according to a list published Monday by Fortune magazine.

"The empress of eBay still rules Silicon Valley," Fortune said in announcing its annual list of the 50 most powerful women in business.

"Though the stock has had a tough year, down about 30 percent, revenues and profits are strong. Whitman has gone shopping, buying seven new businesses for more than $1.3 billion."

Moving off the list is Carly Fiorina, who held the number one spot for years as head of Hewlett-Packard (Research). Fiorina was forced out from HP last February.

Returning to the list at number 21 is Martha Stewart, who recently finished a prison sentence for obstructing justice and lying to investigators during a probe into her sale of ImClone stock.

The rest of the top five include Anne Mulcahy, Chairman and CEO, Xerox (Research) (No. 2); Brenda Barnes, President and CEO, Sara Lee (Research) (No. 3); Oprah Winfrey, Chairman, Harpo (No. 4) and Andrea Jung, Chairman and CEO, Avon (Research) (No. 5).

Fortune ranked the candidates based on the size and importance of the company, their individual clout, their career trajectory and their cultural and social impact.

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For the full Fortune list, click here.

For more names in the news, click here.