Encysive plunges on FDA ruling

Encysive in 50 percent nosedive following negative FDA decision; competing drug from Gilead gets approved.

By Aaron Smith, CNNMoney.com staff writer

NEW YORK (CNNMoney.com) -- The stock price for biotech Encysive Pharmaceuticals plunged more than 50 percent in Monday morning trading, following an FDA decision on Friday to approve a competing heart-lung drug from Gilead while calling Encysive's drug ineffective.

The Food and Drug Administration handed Encysive (Charts) its third "approvable" letter for the drug Thelin, as a treatment for pulmonary arterial hypertension, or high blood pressure in arteries connecting the heart to the lungs. The letter said Thelin was not effective in treating the disease, also known as PAH.

But the FDA approved a PAH drug, known as ambrisentan or Letairis, from Gilead Sciences (down $0.36 to $80.47, Charts). Letairis will compete with Actelion's Tracleer, which totaled $850 million in 2006 sales. Hamed Khorsand, analyst for BWS Financial, projects that annual Letairis sales could reach $600 million by 2012.

Encysive's main competitors include Abbott Laboratories (Charts, Fortune 500) and Sanofi-Aventis (Charts). Top of page

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Most stock quote data provided by BATS. Market indices are shown in real time, except for the DJIA, which is delayed by two minutes. All times are ET. Disclaimer. Morningstar: © 2018 Morningstar, Inc. All Rights Reserved. Factset: FactSet Research Systems Inc. 2018. All rights reserved. Chicago Mercantile Association: Certain market data is the property of Chicago Mercantile Exchange Inc. and its licensors. All rights reserved. Dow Jones: The Dow Jones branded indices are proprietary to and are calculated, distributed and marketed by DJI Opco, a subsidiary of S&P Dow Jones Indices LLC and have been licensed for use to S&P Opco, LLC and CNN. Standard & Poor's and S&P are registered trademarks of Standard & Poor's Financial Services LLC and Dow Jones is a registered trademark of Dow Jones Trademark Holdings LLC. All content of the Dow Jones branded indices © S&P Dow Jones Indices LLC 2018 and/or its affiliates.