The University of Pennsylvania
Donation: $225 million
Donor: Raymond and Ruth Perelman

In May, Raymond Perelman, chairman of RGP Holdings, and his late wife, Ruth, donated $225 million to Penn's School of Medicine -- the largest single gift in the University's history.

Penn President Amy Gutmann called the donation "transformational." The university said that the School of Medicine would increase its financial aid budget by at least 20% for the class entering in 2012. It said it would also use the funds to recruit more medical faculty and educators and invest in medical research programs.

This wasn't the first time the Perelmans donated money to the university. In 2005, the Perelmans pledged $25 million to create the Ruth and Raymond Perelman Center for Advanced Medicine. After this year's donation, the School of Medicine was renamed the Raymond and Ruth Perelman School of Medicine.

By Jessica Dickler @CNNMoney - Last updated December 30 2011: 11:46 AM ET
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Late-year surge in donations

Chalk it up to the holiday spirit -- or just smart tax planning -- but online charitable donations are up 15% so far in December and are expected to rise even further in the final two days of the year.

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