50 Most Powerful Women

In 1998 when the Most Powerful Women in Business list premiered, just two of our honorees ran Fortune 500 companies. This year 13 do.

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1. Indra Nooyi
1. Indra Nooyi
Chairman and CEO
PepsiCo (PEP)
2008 rank: 1
Age: 53

She's back on top for the fourth year, delivering strong profits on $43 billion in sales. Her August deal to buy Pepsi's two biggest bottlers should produce some $300 million in annual cost savings. One weak spot: Consumers panned the rebranding of Gatorade and Tropicana.
By Jessica Shambora and Beth Kowitt

NEXT: 2. Irene Rosenfeld
Last updated September 15 2009: 12:58 PM ET
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