20 most profitable companies

Profits fell by 12% to $21.5 billion at the banking giant in 2006. But it still ranks as the third most profitable company on the list. In the face of dwindling earnings, it's not surprising there have been changes: CEO Chuck Prince brought in a new COO, Robert Druskin, while CFO Sallie Krawcheck moved to the global wealth management unit. Layoffs of 17,000 were announced in April.