In the northern part of the country, a house with most of its windows facing south will collect more light - and therefore more heat - in the winter. (You'll also be able to keep the lightbulbs off until late in the day.)
If you live in warmer climes, it's smart to have most of your windows facing north so your home doesn't bake all year.
In general you want fewer and smaller windows. That's because every window costs: Even the best of them will rot and leak over time. And even deluxe triple-glazed, argon-gas-filled windows will let out more of your home's heat than a wall would.
By the way, the super-insulated variety probably won't save enough to pay back the steep premium - maybe twice the price - over the up-to-code double-glazed kind.
NEXT: Adding up the bill