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5. Amgen
Amgen
Fortune 500 rank: 168
2008 revenue: $15 billion
2008 total shareholder return: 24.4%

Analysts grew bullish when Amgen's osteoporosis drug, denosumab, showed promising clinical trial results. But even the top biotech company's stable of existing drugs posted better-than-expected sales in 2008.

NEXT: Omnicare
Last updated April 20 2009: 1:34 PM ET
2009 Fortune 500
Top 50
Top 50
Exxon Mobil pushes Wal-Mart aside to retake the No. 1 slot this year. Which other companies made the top 50 this year? More
They're hiring!
They're hiring!
As many big companies are announcing mass layoffs, these Fortune 100 employers have at least 150 openings each. More
The biggest losers
The biggest losers
Companies from AIG to United Airlines, from ConocoPhillips to Motorola lost billions of dollars last year. Who lost the most? More
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