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Toyota Prius
Toyota Prius
Overall mpg: 46
Est. annual fuel cost: $1019
Lowest base price: $21,100
The Prius has gone from a cult favorite to a real mass-market hit for Toyota. Although usually thought of as a small car, the it qualifies as a mid-sized sedan based on its copious interior space.

NEXT: Honda Civic Hybrid
Last updated March 12 2008: 4:27 AM ET
Source: Fuel economy and cost estimates, EPA