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Isaac Mizrahi for Target

Though Isaac Mizrahi dazzled insiders with his high-end women's wear in the '80s and '90s, his five-year Target collection, starting in 2003, proved to be his most lucrative line.

Mizrahi's playful looks, accessories, housewares, and bedding nabbed him as much as $300 million a year, making him arguably the movement's most successful designer -- before he decamped for Liz Claiborne in 2008.

--J.P.M.

NEXT: Kate Moss for Topshop

Last updated September 13 2010: 5:51 AM ET
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