Fortune 500 rank: 326
2010 revenue: $7.2 billion
10-year annualized return: -10.8%
Fifth Third was a Wall Street favorite in the '90s, a growing Midwest bank with a solid balance sheet. But after lots of acquisitions, executives neglected the bank's infrastructure, and in time the bank became too decentralized to properly manage.
Problems culminated during the credit crisis when Fifth Third posted huge loan losses across its primary markets in Ohio, Michigan, and Florida.
One prominent analyst recently called Fifth Third a takeover target, but for now the stock continues to languish.
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Last updated May 05 2011: 2:52 PM ET