$3,000 a night
Think of this Four Seasons suite as an antidote to all things Vegas. Sequestered on the top five floors of the Mandalay Bay Hotel, the Four Seasons is far removed from the din of the slot machines. In fact, it's the only resort on this list without its own casino. The floor-to-ceiling windows offer expansive views of a wide-open desert panorama, rather than the strip's bright lights. The four-star, five-diamond hotel is arguably the nicest in Las Vegas but, because of its tranquility, is not really suited to those that want to party. In fact, the one-bedroom suite, which is outfitted with a baby grand piano, a deep soaking whirlpool tub and even an espresso maker, can be configured as a two-or three-bedroom suite by adding connecting rooms, making it well suited for (gasp) families.