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Loser: Lexus GS 450h
Cost: $60,425
Fuel economy (CR test): 23 mpg
Total 5-year savings: -$5,500 (loss)

The GS 450h's hybrid drive system is tuned more for performance than for ultimate fuel savings. Since it gets just three more miles per gallon than the non-hybrid car, the 450h is the biggest cost-effectiveness loser in this bunch, according to Consumer Reports.

Also, Toyota Motor Co. vehicles, which include Lexus cars and SUVs, no longer qualify for federal tax credits.

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