Company: IBM
Fortune 500 rank: 18
First year as CEO: 2012
Most Powerful Women rank: 7
A 30-year IBM veteran, she added marketing and strategy oversight to her role last year. The move positioned her as one of the company's top two candidates to replace current CEO Sam Palmisano, and it worked. Rometty will be Big Blue's next CEO, replacing Palmisano in January.
NEXT: Heather Bresch