11. YRC Worldwide
Jobs lost: 19,000
% drop (1 year): 35%
Remaining employees*: 36,000
Fortune 500 rank: 396
The freight and trucking company was hit hard by the recession and hasn't turned a profit since 2006, resulting in a reorganization and mass layoffs to cut costs. Last year, the company cut more than a third of its workforce and has laid off more employees since January.
NEXT: United Parcel Service
Last updated May 13 2010: 9:10 AM ET
* Full-time equivalent employees as of the end of 2009
