Fortune 500 rank: 39 (Previous rank: 31)
2006 Revenues (millions): $52,415
Headquarters: New York, NY
Get quote: PFE
New CEO Jeffrey Kindler began cutting costs at the drug manufacturer after he took the reins from Hank McKinnell in July. Sales have been flat - up just 2% - in the face of competition from generic drugs. But layoffs, budget cuts, and the sale of the company's consumer products division to Johnson & Johnson helped profits jump 139% to $19.3 billion.
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