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15 companies that will change the world

These game-changing startups are likely to upend existing industries - and spawn new entrepreneurial opportunities.

Raydiance
Schuler wants Raydiance lasers to replace standard cutting tools in every industry, from lumberyards to aerospace factories.
Raydiance
CEO: Barry Schuler
Disruption: Lasers that cut without heating surrounding material
Disrupted: The entire laser industry -- medicine, aerospace, and beyond

Raydiance's ultrashort pulse laser is more accurate than the standard fare in the industry, and when properly tuned, it can blast away at anything from a hunk of steel to a single cancer cell. Though researchers have been using USP lasers since 1989, they've been unmanageably large and notoriously difficult to operate - but Raydiance has managed to shrink its product down to the size of a microwave.

Blinkx

Raydiance

Expensr

Zipcar

MFG.com

Virgin Charter

PatientsLikeMe

Bloom Energy

Vanu

Zink

A123 Systems

Renewable Energy Group

Desktop Factory

Cree

One laptop per child
The New Disruptors video series Editor-at-Large Erick Schonfeld discovers startups with the potential to overturn existing industries or open up entirely new markets. (more)
Tomorrow's light With companies developing innovative ways to fight global warming, Cree founder John Edmond describes how LED lights are poised to change the way we see things. (more) video
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