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59. Syracuse, N.Y.
Population: 144,755
Pro: Commute times are minimal
Con: Seed capital scarce for early-stage companies

Syracuse's strongest industries include pharmaceuticals and renewable energy, thanks in part to the State University of New York's Upstate Medical University and College for Environmental Science and Forestry. With SUNY right there and prestigious colleges and universities such as Cornell within an hour's drive, Syracuse entrepreneurs can tap into a pool of young talent.

Syracuse is a mature city, with an opera, a symphony and a Museum of Science and Technology as well as an annual international film festival. It gets a lot of snow, but for those who like to be outdoors, the nearby Oneida Lake offers scenery, fishing and water sports in the summer. -Malika Zouhali-Worrall

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NEXT: 60. Pittsburgh

Last updated July 02 2008: 11:16 AM ET
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