2006 rank: New
Age: 51
Greene has run VMware since founding it in 1998 with her husband, Mendel Rosenblum. She sold the company to EMC in 2004 for $625 million, then stayed on to continue running it. Still majority-owned by EMC but spun off in an August IPO, VMware is the fastest-growing and most influential enterprise software company Silicon Valley has seen in a decade - and worth a cool $26 billion.