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12. Cisco Systems
Fortune rank: 12
2008 profit: $8.05 Billion
Cisco, the tech giant known for Internet routers and networking equipment, continued growing in new areas like data storage and video conferencing.

Profits grew 10% to $8.1 billion in 2008. Led by CEO John Chambers, the company increased cash reserves to $26 billion as other Silicon Valley firms struggled to survive the downturn.

NEXT: Merck
Last updated April 20 2009: 11:09 AM ET
2009 Fortune 500
Top 50
Top 50
Exxon Mobil pushes Wal-Mart aside to retake the No. 1 slot this year. Which other companies made the top 50 this year? More
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They're hiring!
As many big companies are announcing mass layoffs, these Fortune 100 employers have at least 150 openings each. More
The biggest losers
The biggest losers
Companies from AIG to United Airlines, from ConocoPhillips to Motorola lost billions of dollars last year. Who lost the most? More
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