![Angela Braly](https://i2.cdn.turner.com/money/galleries/2008/fortune/0809/gallery.women_mostpowerful.fortune/images/angela_braly.jpg)
Age: 47
Braly's first year as CEO of Wellpoint has been tough. Second-quarter earnings were down 10%, and the stock has dropped 40% over the past year because of declining enrollment in its core business. Still, Wellpoint is the largest woman-led company in the U.S. in terms of revenue.
NEXT: Andrea Jung
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Last updated October 16 2008: 10:16 AM ET